Parameter
| Biomarker | Serum HBV RNA | Full name | Serum Hepatitis B Virus RNA | Molecular Type | Nucleic acids |
|---|---|---|---|---|---|
| Molecular Formula | HBV RNA (genotype B): Variable sequence (typical ~3.2 kb) | Molecular Weight | ~1.06 MDa (per 3.2 kb strand) | Core Functional Dimensions | Virus replication monitoring, treatment response evaluation, prognosis prediction |
| Disease | Viral Hepatitis | Disease Subtypes | / | ||
| Organ | Liver | Test Sample / Technology Platform | Serum | ||
| Pathobiological Mechanisms | The transcription products directly derived from covalently closed circular DNA (cccDNA) can accurately reflect the transcription activity of cccDNA. It can predict HBeAg/HBsAg seroconversion, recurrence after treatment and the risk of HCC | ||||
| Clinical Availability Status | Clinical research phase | ||||
| Notes and Dynamics | As a non-invasive surrogate marker of cccDNA activity, it has important potential in the management of chronic hepatitis B and can make up for the shortage of existing markers. However, standardized detection methods are needed to promote clinical application | ||||