Parameter
| Biomarker | Hepatitis B surface antigen (HBsAg) and its subtypes: LHB, MHB, SHB | Full name | Hepatitis B surface antigen and its subtypes: Large Hepatitis B Surface Antigen, Middle Hepatitis B Surface Antigen, Small Hepatitis B Surface Antigen | Molecular Type | Proteins |
|---|---|---|---|---|---|
| Molecular Formula | Human HBsAg (SHB): C₂₂₆H₃₄₈N₅₄O₆₂S₂; LHB: C₄₃₋₄⁷ kDa subtype; MHB: C₃₋₄₂ kDa subtype | Molecular Weight | ~24 kDa (SHB), ~36 kDa (MHB), ~42 kDa (LHB) | Core Functional Dimensions | Diagnosis of viral infection, assessment of immune status, determination of treatment endpoint |
| Disease | Viral Hepatitis | Disease Subtypes | / | ||
| Organ | Liver | Test Sample / Technology Platform | Serum | ||
| Pathobiological Mechanisms | Viral envelope proteins, whose subtypes are involved in the process of viral adsorption to hepatocytes and immune escape; Changes in the proportion of subtypes can indicate the stage of infection and treatment response, which is the core evaluation index for functional cure | ||||
| Clinical Availability Status | Markers are routinely used in clinical practice | ||||
| Notes and Dynamics | As the gold standard for the diagnosis of HBV infection, subtype analysis can improve the accuracy of disease staging and prognosis, and is a key target for vaccine development and new antiviral drugs, which needs to be optimized in combination with high-sensitivity detection techniques | ||||