Parameter
| Biomarker | Alkaline phosphatase (ALP) | Full name | Alkaline phosphatase | Molecular Type | Enzymes |
|---|---|---|---|---|---|
| Molecular Formula | Human ALP (isoform liver/bone/kidney): C₁₀₈₀H₁₇₀₄N₂₈₈O₃₂₄P₆Zn₂ | Molecular Weight | ~240 kDa | Core Functional Dimensions | Diagnosis of cholestasis and identification of types of liver injury |
| Disease | Viral Hepatitis | Disease Subtypes | / | ||
| Organ | Liver | Test Sample / Technology Platform | Serum | ||
| Pathobiological Mechanisms | They were mainly expressed in hepatobiliary epithelial cells and increased significantly in cholestasis. Combined with GGT, hepatocyte injury (ALT/AST mainly increased) and cholestatic injury (ALP/GGT mainly increased) could be distinguished. It is used for monitoring the efficacy of primary biliary cholangitis (PBC) | ||||
| Clinical Availability Status | Routine clinical use | ||||
| Notes and Dynamics | The core index for the diagnosis of cholestatic liver disease combined with GGT can improve the diagnostic specificity, and is an important tool for the classification and treatment monitoring of hepatobiliary diseases | ||||