Parameter
| Biomarker | Fibrosis-4 index (FIB-4) | Full name | Fibrosis-4 index | Molecular Type | Composite index (AST, ALT, platelet, age) |
|---|---|---|---|---|---|
| Molecular Formula | Staging of liver fibrosis and risk assessment of cirrhosis | Molecular Weight | Core Functional Dimensions | ||
| Disease | Viral Hepatitis | Disease Subtypes | / | ||
| Organ | Liver | Test Sample / Technology Platform | Serum (all the required indicators for calculation are routine tests) | ||
| Pathobiological Mechanisms | Based on AST, ALT, platelet count and age, the degree of liver fibrosis was reflected by comprehensive indicators. FIB-4 < 1.45 indicates no advanced fibrosis, and FIB-4 > 3.25 indicates high risk | ||||
| Clinical Availability Status | Routine clinical use (as one of the preferred tools for non-invasive fibrosis assessment) | ||||
| Notes and Dynamics | These simple, inexpensive non-invasive markers are suitable for large-scale screening in the primary care setting. However, ELF™ and FibroScan should be combined for further evaluation in patients with intermediate values (1.45-3.25) | ||||