Parameter
| Biomarker | Short-chain fatty acids (SCFA, such as acetic acid, propionic acid, butyrate) | Full name | propionic acid, butyrate) Short-chain fatty acids (acetic acid, propionic acid, butyrate) | Molecular Type | Metabolites |
|---|---|---|---|---|---|
| Molecular Formula | Acetic acid: C₂H₄O₂; Propionic acid: C₃H₆O₂; Butyrate: C₄H₈O₂ | Molecular Weight | Acetic acid: 60.05 Da; Propionic acid: 74.08 Da; Butyrate: 88.11 Da | Core Functional Dimensions | Intestinal barrier maintenance, liver inflammation regulation |
| Disease | Viral Hepatitis | Disease Subtypes | / | ||
| Organ | Liver/Gut | Test Sample / Technology Platform | Stool and serum | ||
| Pathobiological Mechanisms | Gut microbiota metabolize the main products of dietary fiber and inhibit liver inflammation through GPR41/GPR43 receptors. Butyrate can promote the tight junction of intestinal epithelial cells and reduce the inflow of LPS into the blood. The decrease of SCFA level indicates the dysfunction of gut-liver axis | ||||
| Clinical Availability Status | Clinical research phase | ||||
| Notes and Dynamics | "Functional markers" of gut microbiota metabolism, levels of which are inversely correlated with MASLD and severity of cirrhosis, can be used to evaluate the efficacy of microbiota-modulating therapies such as prebiotics. Standardized methods are needed | ||||