Parameter
| Biomarker | HBV-DNA/HCV-RNA | Full name | Hepatitis B Virus DNA / Hepatitis C Virus RNA | Molecular Type | Nucleic acid (viral nucleic acid) |
|---|---|---|---|---|---|
| Molecular Formula | HBV-DNA (genotype C): ~3.2 kb double-stranded DNA; HCV-RNA (genotype 1a): ~9.6 kb single-stranded RNA | Molecular Weight | HBV-DNA: ~1.06 MDa (per 3.2 kb); HCV-RNA: ~3.1 MDa (per 9.6 kb) | Core Functional Dimensions | Diagnosis, efficacy monitoring and prognosis |
| Disease | Viral Hepatitis | Disease Subtypes | / | ||
| Organ | Liver | Test Sample / Technology Platform | Serum (qPCR, digital PCR) | ||
| Pathobiological Mechanisms | HBV/HCV replicates in hepatocytes after infection. Viral nucleic acid is the direct evidence of the presence and replication activity of the virus, and its load reflects the severity of infection and the effect of treatment. | ||||
| Clinical Availability Status | Routine clinical use: core diagnostic and monitoring markers, included in the diagnosis and treatment guidelines. | ||||
| Notes and Dynamics | Viral nucleic acid detection is the "gold standard" for the etiological diagnosis and treatment response evaluation of viral hepatitis, with high specificity and sensitivity, and the core basis for guiding clinical medication adjustment. | ||||