Parameter
| Biomarker | IDH1/2 (mutation) | Full name | Isocitrate dehydrogenase 1/2 mutations | Molecular Type | Nucleic acid (DNA mutation) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis, selection of targeted therapy | ||
| Disease | Cholangiocarcinoma (CCA) | Disease Subtypes | / | ||
| Organ | Bile duct/Liver | Test Sample / Technology Platform | Tissue/plasma/bile (NGS, ddPCR) | ||
| Pathobiological Mechanisms | Mutations lead to the accumulation of 2-hydroxyglutaric acid (2-HG), inhibit cell differentiation, and promote tumorigenesis | ||||
| Clinical Availability Status | Clinically available (targeted therapy option); iCCA is common | ||||
| Notes and Dynamics | |||||