Parameter
| Biomarker | cfDNA (cell-free DNA) | Full name | Cell-free DNA | Molecular Type | Nucleic acids (fragments of DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | 150-200 bp | Core Functional Dimensions | Diagnosis and Prognosis | |
| Disease | Cholangiocarcinoma (CCA) | Disease Subtypes | / | ||
| Organ | Bile duct/Liver | Test Sample / Technology Platform | Plasma/bile (NGS, methylation sequencing) | ||
| Pathobiological Mechanisms | It contains tumor-derived ctDNA, reflecting the overall genomic characteristics of the tumor; Aberrant methylation is tumor specific | ||||
| Clinical Availability Status | Study validation; Methylation detection can improve the efficiency of early diagnosis | ||||
| Notes and Dynamics | cfDNA methylation panels (such as OPCML and HOXD9) had a specificity of 100% in differentiating CCA from benign biliary diseases. Early detection sensitivity 76%, specificity 94% RRBS techniques | ||||