Parameter
| Biomarker | miR-21 | Full name | microRNA-21 | Molecular Type | Nucleic acid (miRNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis and drug resistance monitoring | ||
| Disease | Cholangiocarcinoma (CCA) | Disease Subtypes | / | ||
| Organ | Bile duct/Liver | Test Sample / Technology Platform | / plasma/serum bile (qRT PCR and NGS) | ||
| Pathobiological Mechanisms | Targeting PTEN, PDCD4, promote tumor proliferation, invasion, and gemcitabine/cisplatin resistance | ||||
| Clinical Availability Status | The validation; High expression suggests poor prognosis | ||||
| Notes and Dynamics | Associated with EMT, restrain can be enhanced after chemotherapy sensitivity; Serum/high expression of bile, can be used as a noninvasive diagnostic markers | ||||