Parameter
| Biomarker | miR-221/222 | Full name | microRNA-221/222 | Molecular Type | Nucleic acid (miRNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis and prognosis | ||
| Disease | Cholangiocarcinoma (CCA) | Disease Subtypes | / | ||
| Organ | Bile duct/Liver | Test Sample / Technology Platform | Serum/bile (qRT - PCR) | ||
| Pathobiological Mechanisms | Targeted p27, PTEN, promote cell cycle progression and apoptosis resistance | ||||
| Clinical Availability Status | Study validation; It was highly expressed in iCCA | ||||
| Notes and Dynamics | High expression of ICCA indicates strong invasion and is associated with poor prognosis. Inhibition of the expression can reduce the tumor proliferation activity | ||||