Parameter
| Biomarker | miR-34a | Full name | microRNA-34a | Molecular Type | Nucleic acid (miRNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis and therapeutic targets | ||
| Disease | Cholangiocarcinoma (CCA) | Disease Subtypes | / | ||
| Organ | Bile duct/Liver | Test Sample / Technology Platform | Serum/plasma (qRT PCR and NGS) | ||
| Pathobiological Mechanisms | Targeted Notch, the Bcl - 2, inhibition of tumor proliferation and induce apoptosis | ||||
| Clinical Availability Status | Developing clinical validation (therapy); Tumor suppressor mirnas | ||||
| Notes and Dynamics | Mimic (MRX34) in clinical trials, used to restore tumor suppressor function; Low expression of MRX34 is associated with tumor progression | ||||