Parameter
| Biomarker | 2-Hydroxyglutaric acid (2-HG) | Full name | D-2-hydroxyglutaric acid | Molecular Type | metabolites |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis and targeted therapy monitoring | ||
| Disease | Cholangiocarcinoma (CCA) | Disease Subtypes | / | ||
| Organ | Bile duct/Liver | Test Sample / Technology Platform | Serum (liquid chromatography - mass spectrometry) | ||
| Pathobiological Mechanisms | Characteristic metabolites of IDH1/2 mutated tumors, which promote tumorigenesis and progression | ||||
| Clinical Availability Status | Clinical validation; Patient-specific markers for IDH mutations | ||||
| Notes and Dynamics | Levels associated with the tumor load, can be real-time monitoring ivosidenib treatment response; Diagnosis of IDH mutation CCA sensitivity 83%, specificity of 90% | ||||