Parameter
| Biomarker | Alpha-fetoprotein (AFP) | Full name | Alpha-fetoprotein | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis, and prediction of treatment response | ||
| Disease | Hepatocellular Carcinoma (HCC) - | Disease Subtypes | / | ||
| Organ | Liver | Test Sample / Technology Platform | Serum/plasma (ELISA, RIA) | ||
| Pathobiological Mechanisms | Embryonic proteins abnormally expressed by hepatocellular carcinoma cells are involved in tumor proliferation and immunosuppression | ||||
| Clinical Availability Status | Clinically available (routine screening) : the sensitivity of single detection is 47-64%, and can be increased to 63% when combined with ultrasound | ||||
| Notes and Dynamics | The traditional core marker AFP≥400 ng/mL can predict the benefit of ramucirumab treatment. A decrease of >20% at 2-8 weeks after treatment indicated a good response | ||||