Parameter
| Biomarker | Outside the secrete body related markers (EV - derived GPC3, AFP mRNA, miR - 21-5 p) | Full name | Extracellular vesicle (Exosome)-derived markers (e.g., GPC3 protein/mRNA, AFP mRNA, miR-21-5p) | Molecular Type | Cell derivatives (containing protein /RNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, prognosis, and monitoring | ||
| Disease | Hepatocellular Carcinoma (HCC) - | Disease Subtypes | / | ||
| Organ | Liver | Test Sample / Technology Platform | Serum/plasma lactate (overspeed centrifugal + ELISA/qRT - PCR) | ||
| Pathobiological Mechanisms | Exosomes released by tumor cells carry tumor-specific molecules and mediate intercellular communication | ||||
| Clinical Availability Status | This study verified that the diagnostic efficiency of exosomal GPC3 was better than that of serum GPC3 | ||||
| Notes and Dynamics | Exosomal proteins such as CCT8 and CFL1 are related to vascular invasion and can be used for prognostic stratification | ||||