Parameter
| Biomarker | Microsatellite Instability (MSI) | Full name | Microsatellite Instability | Molecular Type | Nucleic acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Predicting response to immunotherapy | ||
| Disease | Hepatocellular Carcinoma (HCC) - | Disease Subtypes | / | ||
| Organ | Liver | Test Sample / Technology Platform | Tumor Tissue /ctDNA (NGS) | ||
| Pathobiological Mechanisms | DNA mismatch repair defects lead to abnormal microsatellite sequences and enhance immunogenicity | ||||
| Clinical Availability Status | The incidence of MSI-H in HCC is low (<5%), and it only has predictive value for some patients | ||||
| Notes and Dynamics | MSI -h HCC patients may benefit from PD - 1 inhibitor treatment | ||||