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Parameter
Biomarker Intestinal flora (Lachnospiraceae bacterium - GAM79, Veillonellaceae, etc.) Full name Gut microbiota (e.g., specific taxa) Molecular Type microbial
Molecular Formula Molecular Weight Core Functional Dimensions To predict response to immunotherapy
Disease Hepatocellular Carcinoma (HCC) Disease Subtypes /
Organ Liver Test Sample / Technology Platform Stool (16S rRNA sequencing)
Pathobiological Mechanisms Through the gut - regulating the liver immune liver axis, ICIs curative effect
Clinical Availability Status Frontier research: Enrichment of specific microbiota is associated with benefit from immunotherapy
Notes and Dynamics Joint metabolites (such as galanthaminone) can improve the prediction accuracy

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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