Parameter
| Biomarker | p-tau (181, 217) | Full name | Phosphorylated Tau (at threonine 181, 217) | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis, Prognosis | ||
| Disease | Liver Cirrhosis | Disease Subtypes | / | ||
| Organ | Liver | Test Sample / Technology Platform | CSF/plasma (SIMOA, IP-MS) | ||
| Pathobiological Mechanisms | Hyperphosphorylation of Tau leads to neurofibrillary tangles that disrupt the neuronal cytoskeleton. p-tau is a direct product of this process. | ||||
| Clinical Availability Status | Clinical validation/guideline recommendation: CSF p-tau is the core marker for the diagnosis of AD; Plasma p-tau217 showed excellent diagnostic performance. | ||||
| Notes and Dynamics | p-tau217 is more specific than p-tau181 and is a star molecule for the next generation of blood markers. | ||||