Parameter
| Biomarker | Golgi protein 73 (GP73) | Full name | Golgi protein 73 / Golgi membrane protein 1 (GOLM1) | Molecular Type | Proteins |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | |||
| Disease | Liver Cirrhosis | Disease Subtypes | / | ||
| Organ | Liver | Test Sample / Technology Platform | Serum (ELISA, chemiluminescence immunoassay, latex particle-enhanced turbidimetry, etc.) | ||
| Pathobiological Mechanisms | Involved in inflammation and fibrosis related pathological process, when the liver injury significantly increased expression in liver cells, serum level is associated with severe cirrhosis. | ||||
| Clinical Availability Status | Validation/clinical exploration: several studies have confirmed that the serum GP73 significantly increased in patients with cirrhosis of the liver, some studies have shown that the diagnosis accuracy of medium, can be used as a noninvasive alternative markers. | ||||
| Notes and Dynamics | The comparability of different detection methods is not clear, and the individual variability is insufficient. Further large-scale clinical validation is needed to determine the uniform cut-off value. | ||||