Parameter
| Biomarker | Microrna (miR-21, miR-29, miR-122, etc.) | Full name | MicroRNAs (e.g., miR-21, miR-29a/b/c, miR-122) | Molecular Type | Nucleic acid (RNA) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Diagnosis and prognosis | ||
| Disease | Liver Cirrhosis | Disease Subtypes | / | ||
| Organ | Liver | Test Sample / Technology Platform | Serum/plasma (qRT-PCR, sequencing technology) | ||
| Pathobiological Mechanisms | miR-21 promotes the activation of hepatic stellate cells. Down-regulation of miR-29 leads to excessive synthesis of collagen. miR-122 is involved in the regulation of hepatocyte injury and fibrosis. | ||||
| Clinical Availability Status | Validation: several studies have confirmed that the abnormal expression in patients with cirrhosis of the liver, has potential diagnostic and prognostic value. | ||||
| Notes and Dynamics | Different cause of cirrhosis in the tiny RNA expression patterns vary, specific diagnostic markers, is expected to be the cause. | ||||