Parameter
| Biomarker | Albumin | Full name | Albumin | Molecular Type | Protein (proteins synthesized by the liver) |
|---|---|---|---|---|---|
| Molecular Formula | Molecular Weight | Core Functional Dimensions | Assessment of liver function, prognosis, and severity of the disease | ||
| Disease | Liver Cirrhosis | Disease Subtypes | / | ||
| Organ | Liver | Test Sample / Technology Platform | Serum (biochemical analyzer, by immunoturbidimetric assay, bromocresol green assay, etc.) | ||
| Pathobiological Mechanisms | Albumin is synthesized by hepatocytes and is the core index reflecting the synthetic function of the liver. In liver cirrhosis, there is extensive degeneration and necrosis of hepatocytes, the structure of liver lobules is destroyed, and the ability to synthesize albumin continues to decline. At the same time, liver cirrhosis is often accompanied by portal hypertension caused by vascular bed dilatation and insufficient effective circulating blood volume, which leads to increased renal reabsorption of water and sodium, and the dilution of plasma albumin, which further leads to the decrease of serum albumin level. Its level is directly related to liver cirrhosis Child - Pugh, classification, the lower the level of tip liver function reserve. | ||||
| Clinical Availability Status | Clinical routine use: as the core of cirrhosis of the liver function evaluation, classification and prognosis judgement markers, be incorporated into the Child - Pugh, scoring system such as international general guidelines, clinical application of mature. | ||||
| Notes and Dynamics | Albumin is the most intuitive and commonly used indicator to evaluate the liver synthetic function in patients with cirrhosis. It is easy to operate, low-cost and stable, and can effectively reflect the liver function reserve. However, it should be noted that non-hepatic factors such as malnutrition, severe infection, and kidney disease may also lead to decreased albumin, and clinical interpretation should be combined with the patient's overall condition to exclude interference. | ||||