Parameter
| Biomarker | BDNF | Full name | Brain-Derived Neurotrophic Factor | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Prognosis, Disease Monitoring |
| Disease | Depression | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Plasma/Serum (ELISA, Luminex) | ||
| Pathobiological Mechanisms | Neuroplasticity decreases, neuronal survival/differentiation are impaired, synaptic dysfunction occurs, and levels can be upregulated after antidepressant treatment. | ||||
| Clinical Availability Status | Under Clinical Validation | ||||
| Notes and Dynamics | Levels are significantly decreased in treatment-resistant depression patients, positively correlated with serotonergic system activity. | ||||