Parameter
| Biomarker | Cortisol | Full name | Cortisol | Molecular Type | Hormone |
|---|---|---|---|---|---|
| Molecular Formula | C21H30O5 | Molecular Weight | 362.46 g/mol | Core Functional Dimensions | Diagnosis, Disease Monitoring, Prognosis |
| Disease | Depression | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Saliva/Plasma (Chemiluminescence Immunoassay, Radioimmunoassay) | ||
| Pathobiological Mechanisms | HPA axis negative feedback regulation dysfunction; excessive secretion inhibits hippocampal neuronal proliferation and reduces glucocorticoid receptor sensitivity. | ||||
| Clinical Availability Status | Clinically Available | ||||
| Notes and Dynamics | Abnormal morning cortisol peak (>25μg/dL) indicates HPA axis dysfunction, and can monitor SSRI treatment response. | ||||