Parameter
| Biomarker | ACTH | Full name | Adrenocorticotropic Hormone | Molecular Type | Hormone |
|---|---|---|---|---|---|
| Molecular Formula | C131H209N43O31S | Molecular Weight | 2933.38 g/mol | Core Functional Dimensions | Diagnosis, Etiological Confirmation |
| Disease | Depression | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Plasma (Chemiluminescence Immunoassay) | ||
| Pathobiological Mechanisms | HPA axis negative feedback regulation dysfunction; excessive secretion inhibits hippocampal neuronal proliferation and reduces glucocorticoid receptor sensitivity. | ||||
| Clinical Availability Status | Clinically Available | ||||
| Notes and Dynamics | Abnormal morning cortisol peak (>25μg/dL) indicates HPA axis dysfunction, and can monitor SSRI treatment response. | ||||