Parameter
| Biomarker | TNF-α | Full name | Tumor Necrosis Factor α | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | C157H251N43O46S2 | Molecular Weight | 3418.07 g/mol | Core Functional Dimensions | Diagnosis, Prognosis |
| Disease | Depression | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Serum (ELISA, Luminex) | ||
| Pathobiological Mechanisms | Pro-inflammatory response disrupts blood-brain barrier integrity, induces astrocyte activation, and reduces presynaptic serotonin release. | ||||
| Clinical Availability Status | Under Clinical Validation | ||||
| Notes and Dynamics | Levels are significantly elevated in treatment-resistant depression patients (>8pg/mL); anti-TNF-α therapy (e.g., etanercept) can improve depressive symptoms. | ||||