Parameter
| Biomarker | 5-HT | Full name | Serotonin | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | C10H12N2O | Molecular Weight | 76.21 g/mol | Core Functional Dimensions | Diagnosis, Etiological Confirmation |
| Disease | Depression | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Serum/Cerebrospinal Fluid (High-Performance Liquid Chromatography HPLC, Mass Spectrometry) | ||
| Pathobiological Mechanisms | Decreased serotonin concentration in the synaptic cleft affects the emotional regulation pathway of the limbic system-prefrontal cortex. | ||||
| Clinical Availability Status | Research Stage | ||||
| Notes and Dynamics | Selective Serotonin Reuptake Inhibitors (SSRIs) exert efficacy by increasing its levels; cerebrospinal fluid 5-HT is negatively correlated with depression-related suicide risk. | ||||