Parameter
| Biomarker | TRP/KYN | Full name | Tryptophan/Kynurenine Ratio | Molecular Type | Amino Acid Metabolite |
|---|---|---|---|---|---|
| Molecular Formula | C11H12N2O2/C10H12N2O3 | Molecular Weight | 204.23/208.21 g/mol | Core Functional Dimensions | Pathological Confirmation, Etiological Confirmation |
| Disease | Depression | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Plasma (LC-MS, High-Performance Liquid Chromatography HPLC) | ||
| Pathobiological Mechanisms | Inflammation-induced elevation of IDO/TDO enzyme activity shifts tryptophan metabolism toward the kynurenine pathway, leading to accumulation of the neurotoxic QUINA. | ||||
| Clinical Availability Status | Research Validation Stage | ||||
| Notes and Dynamics | A ratio <20 indicates inflammation activation, associated with impaired executive function in depression patients (increased error rate in WCST). | ||||