Parameter
| Biomarker | QUINA | Full name | Quinolinic Acid | Molecular Type | Amino Acid Metabolite |
|---|---|---|---|---|---|
| Molecular Formula | C7H6N2O4 | Molecular Weight | 178.13 g/mol | Core Functional Dimensions | Pathological Confirmation |
| Disease | Depression | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Cerebrospinal Fluid (LC-MS/MS) | ||
| Pathobiological Mechanisms | A neurotoxic metabolite of tryptophan metabolism that excessively activates NMDA receptors and induces excitotoxic injury of hippocampal neurons. | ||||
| Clinical Availability Status | Research Stage | ||||
| Notes and Dynamics | Cerebrospinal fluid QUINA levels in patients with chronic depression are 3.2 times higher than those in healthy individuals, negatively correlated with hippocampal volume reduction. | ||||