Parameter
| Biomarker | P2X7R | Full name | P2X Purinoceptor 7 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Prediction, Pharmacodynamics/Response |
| Disease | Epilepsy | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Serum/Brain Region Tissue (ELISA, PET Imaging) | ||
| Pathobiological Mechanisms | Activates the NLRP3 inflammasome, promotes IL-1β release, mediates anti-epileptic drug (ASM) efflux, leading to treatment resistance. | ||||
| Clinical Availability Status | Research validation stage | ||||
| Notes and Dynamics | The specific antagonist JNJ-47965567 has entered clinical phase II, which can reverse drug resistance in some patients. | ||||