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Parameter
Biomarker SV2A Full name Synaptic Vesicle Protein 2A Molecular Type Protein
Molecular Formula / Molecular Weight / Core Functional Dimensions Prediction, Pharmacodynamics/Response
Disease Epilepsy Disease Subtypes /
Organ Brain Test Sample / Technology Platform Tumor Tissue (Immunohistochemistry, PET Imaging)
Pathobiological Mechanisms A specific binding target of the anti-epileptic drug levetiracetam; expression levels directly affect drug sensitivity.
Clinical Availability Status Under clinical validation
Notes and Dynamics The response rate to levetiracetam is increased by 30% in patients with high SV2A expression; PET imaging can guide individualized medication.

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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