Parameter
| Biomarker | P-gp | Full name | P-Glycoprotein | Molecular Type | Transporter |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Prediction, Pharmacodynamics/Response |
| Disease | Epilepsy | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Brain Microvessels/Plasma (Immunohistochemistry, Western Blot) | ||
| Pathobiological Mechanisms | Overexpressed at the blood-brain barrier, actively pumps out ASMs, reducing intracerebral drug concentration, leading to treatment resistance. | ||||
| Clinical Availability Status | Under clinical validation | ||||
| Notes and Dynamics | COX-2 inhibitors (e.g., celecoxib) can downregulate P-gp expression, reversing multidrug resistance in some patients. | ||||