Parameter
| Biomarker | NfL | Full name | Neurofilament Light Chain | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Monitoring, Prognosis |
| Disease | Multiple Sclerosis | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Serum / CSF (Simoa, ELISA) | ||
| Pathobiological Mechanisms | Released after neuroaxonal injury, reflecting the degree of inflammation and neurodegeneration, correlated with lesion activity and brain atrophy. | ||||
| Clinical Availability Status | Clinical validation / guideline recommendation: Has been incorporated into the clinical monitoring system; Z-score correction for age / BMI improves accuracy. | ||||
| Notes and Dynamics | A decrease 3-6 months after treatment indicates efficacy; sustained elevation predicts relapse and disability progression. | ||||