Parameter
| Biomarker | PRL | Full name | Parametric Rim Lesions | Molecular Type | Imaging Biomarker |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Prognosis |
| Disease | Multiple Sclerosis | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Brain MRI (Susceptibility-sensitive sequences, QSM) | ||
| Pathobiological Mechanisms | A feature of chronic active lesions, iron-loaded microglia surround the demyelinating core, mediating persistent inflammation and neural injury. | ||||
| Clinical Availability Status | Research validation / early clinical use: Standardized detection with 3T MRI is advancing multi-center validation. | ||||
| Notes and Dynamics | Specificity > 90%, strongly correlated with disability progression, a potential efficacy indicator for targeted chronic inflammation therapy. | ||||