Parameter
| Biomarker | SEL | Full name | Slowly Expanding Lesions | Molecular Type | Imaging Biomarker |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Monitoring, Prognosis |
| Disease | Multiple Sclerosis | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Brain MRI (T1/T2 weighted sequences, Jacobian analysis) | ||
| Pathobiological Mechanisms | Radial expansion of chronic lesions visible on conventional MRI, reflecting persistent demyelination and tissue injury, independent of acute inflammation. | ||||
| Clinical Availability Status | Research validation / early clinical use: Requires at least 3 longitudinal scans for confirmation, predicts 9-year disability progression. | ||||
| Notes and Dynamics | Partially overlapping with PRL but not interchangeable; combined detection can comprehensively assess chronic lesion activity. | ||||