Parameter
| Biomarker | CHI3L1 | Full name | Chitinase 3-Like Protein 1 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Prognosis |
| Disease | Multiple Sclerosis | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | CSF / Serum (ELISA) | ||
| Pathobiological Mechanisms | A marker of microglial activation, promotes inflammatory factor release and tissue fibrosis, associated with gray matter atrophy. | ||||
| Clinical Availability Status | Research validation / early clinical use: Levels are significantly higher in PPMS than in RRMS, predicting progression rate. | ||||
| Notes and Dynamics | Combined with NfL can improve PPMS diagnostic accuracy, a potential target for neuroprotective therapy. | ||||