Parameter
| Biomarker | HLA-DRB1*15:01 | Full name | Human Leukocyte Antigen-DRB1*15:01 | Molecular Type | Nucleic Acid (DNA) |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Susceptibility |
| Disease | Multiple Sclerosis | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Whole Blood (Genotyping) | ||
| Pathobiological Mechanisms | Affects immune cell antigen recognition, reduces self-tolerance, increases the risk of myelin-specific T cell activation. | ||||
| Clinical Availability Status | Clinically available (risk assessment): Only used for risk stratification, not for standalone diagnosis. | ||||
| Notes and Dynamics | Highest carrier rate in European populations, a core locus for MS genetic susceptibility; combined with other biomarkers improves risk prediction value. | ||||