Parameter
| Biomarker | TSPO-PET (+) Lesions | Full name | TSPO-PET Positive Lesions | Molecular Type | Imaging Biomarker (Molecular Imaging) |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Monitoring, Prognosis |
| Disease | Multiple Sclerosis | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Brain PET (¹¹C-PK11195, ¹⁸F-DPA714) | ||
| Pathobiological Mechanisms | The 18 kDa transporter is expressed on activated microglia/macrophages, reflecting chronic inflammatory activity. | ||||
| Clinical Availability Status | Research validation / early clinical use: Can detect chronic inflammatory lesions negative on MRI. | ||||
| Notes and Dynamics | New TSPO ligands improve spatial resolution, a efficacy monitoring tool for targeted microglial therapy. | ||||