Parameter
| Biomarker | NfL | Full name | Neurofilament Light Chain | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Prognosis, Disease Monitoring |
| Disease | Frontotemporal Dementia | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Plasma/CSF (SIMOA, ELISA, Luminex) | ||
| Pathobiological Mechanisms | Released after neuronal axonal injury, reflecting the degree of pan-neurodegeneration, positively correlated with gray matter atrophy rate. | ||||
| Clinical Availability Status | Under clinical validation (used in some centers) | ||||
| Notes and Dynamics | Plasma NfL >25pg/mL indicates accelerated progression; levels in bvFTD are higher than in svPPA; combined with MRI the diagnostic accuracy is 89%. | ||||