Parameter
| Biomarker | TDP-43 Agg | Full name | TDP-43 Protein Aggregation (Phosphorylated/Truncated Form) | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Pathological Confirmation, Diagnosis |
| Disease | Frontotemporal Dementia | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | CSF/Skin Biopsy/Brain Biopsy (Western Blot, RT-QuIC, IP-MS) | ||
| Pathobiological Mechanisms | Cytoplasmic aggregation forms inclusions, inhibits RNA metabolism, and induces neuronal apoptosis. | ||||
| Clinical Availability Status | Research stage (under clinical translation) | ||||
| Notes and Dynamics | 95% of FTD-TDP have this pathology; RT-QuIC detection has a sensitivity of 89% and specificity of 98%; the positive rate of skin biopsy is 72% in patients with disease duration <2 years. | ||||