Parameter
| Biomarker | Progranulin | Full name | Progranulin Protein | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Disease Monitoring, Etiological Confirmation |
| Disease | Frontotemporal Dementia | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Plasma/CSF (ELISA, Luminex) | ||
| Pathobiological Mechanisms | GRN mutations cause decreased expression; non-mutant forms decrease due to increased degradation, involved in synaptic repair. | ||||
| Clinical Availability Status | Under clinical validation | ||||
| Notes and Dynamics | Plasma progranulin <10ng/mL suggests GRN mutation; CSF levels in non-mutant forms are negatively correlated with frontotemporal atrophy. | ||||