Parameter
| Biomarker | p-tau181 | Full name | Phosphorylated Tau181 | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Subtype Differentiation |
| Disease | Frontotemporal Dementia | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Plasma/CSF (ELISA, Luminex) | ||
| Pathobiological Mechanisms | Elevated in AD, no significant change in FTD, used to distinguish FTD from AD. | ||||
| Clinical Availability Status | Clinical auxiliary diagnosis | ||||
| Notes and Dynamics | Plasma p-tau181 >6pg/mL suggests AD; most FTD cases have <4pg/mL; combined with CSF Aβ42/Aβ40 the differentiation accuracy is 92%. | ||||