Parameter
| Biomarker | pNfH | Full name | Phosphorylated Neurofilament Heavy Chain | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Prognosis |
| Disease | Amyotrophic Lateral Sclerosis | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | CSF/Plasma (ELISA, Luminex, Single-Molecule Array) | ||
| Pathobiological Mechanisms | NfH is hyperphosphorylated after axonal injury, with enhanced stability; released to reflect the degree of neuronal injury. | ||||
| Clinical Availability Status | Under clinical validation | ||||
| Notes and Dynamics | Plasma pNfH levels in spinal onset ALS patients are 28% higher than in bulbar onset, positively correlated with the annual progression rate of ALSFRS-R; can distinguish ALS from Spinal Muscular Atrophy (SMA). | ||||