Parameter
| Biomarker | YKL-40 | Full name | Chitinase 3-Like Protein 1 | Molecular Type | Protein (Cytokine) |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Pathological Confirmation, Prognosis |
| Disease | Amyotrophic Lateral Sclerosis | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | CSF/Plasma (ELISA, Luminex) | ||
| Pathobiological Mechanisms | Secreted by activated microglia, involved in extracellular matrix remodeling, aggravating neuroinflammation. | ||||
| Clinical Availability Status | Research validation stage | ||||
| Notes and Dynamics | Elevated levels are positively correlated with the rate of cognitive decline, serving as an efficacy monitoring indicator for NLRP3 inhibitors; CSF YKL-40 levels are higher in C9orf72 mutation carriers than in sporadic ALS. | ||||