Parameter
| Biomarker | CK-MB | Full name | Creatine Kinase MB Isoenzyme | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Prognosis |
| Disease | Amyotrophic Lateral Sclerosis | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Serum (Electrochemiluminescence Immunoassay, Immunoturbidimetry) | ||
| Pathobiological Mechanisms | Muscle denervation leads to myocyte membrane injury, and CK-MB is released into the blood. | ||||
| Clinical Availability Status | Clinical auxiliary diagnosis | ||||
| Notes and Dynamics | Serum CK-MB is elevated in 53.8% of ALS patients, positively correlated with cardiac troponin T (cTnT); combined detection distinguishes ALS from ALS-mimics with an accuracy of 86%. | ||||