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Parameter
Biomarker NLR Full name Neutrophil-Lymphocyte Ratio Molecular Type Cell Ratio
Molecular Formula / Molecular Weight / Core Functional Dimensions Prognosis, Inflammation Assessment
Disease Amyotrophic Lateral Sclerosis Disease Subtypes /
Organ Brain Test Sample / Technology Platform Whole Blood (Hematology Analyzer)
Pathobiological Mechanisms Enhanced systemic inflammatory response, increased neutrophils (pro-inflammatory), decreased lymphocytes (immunosuppression).
Clinical Availability Status Clinically available (routine testing)
Notes and Dynamics The survival period of patients with NLR >3 is 42% shorter than those with NLR <2, serving as a non-invasive prognostic indicator; positively correlated with disease progression rate.

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This study was supported by the Scientific Research Innovation Capability Support Project for Young Faculty (SRICSPYF-ZY2025112), the Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM612)

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