Parameter
| Biomarker | miR-206 | Full name | MicroRNA-206 | Molecular Type | Non-coding RNA (microRNA) |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Disease Monitoring |
| Disease | Amyotrophic Lateral Sclerosis | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Plasma/Skeletal Muscle (qPCR, RNA-seq) | ||
| Pathobiological Mechanisms | Regulates myocyte differentiation and neuromuscular junction (NMJ) repair; expression is elevated in ALS to compensate for muscle denervation. | ||||
| Clinical Availability Status | Research stage | ||||
| Notes and Dynamics | miR-206 levels in skeletal muscle are negatively correlated with the degree of myofiber atrophy; supplementation of miR-206 can improve NMJ function in SOD1 G93A mouse models. | ||||