Parameter
| Biomarker | IL-6 | Full name | Interleukin-6 | Molecular Type | Protein (Cytokine) |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Pathological Confirmation, Prognosis |
| Disease | Amyotrophic Lateral Sclerosis | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | CSF/Serum (ELISA, Luminex) | ||
| Pathobiological Mechanisms | Secreted by activated microglia, activates the JAK-STAT pathway, promoting neuronal apoptosis. | ||||
| Clinical Availability Status | Research validation stage | ||||
| Notes and Dynamics | Serum IL-6 levels in ALS patients with depression are positively correlated with HAMD scores; anti-IL-6 drugs (tocilizumab) can reduce IL-6 levels in the brains of model mice. | ||||