Parameter
| Biomarker | sTREM2 | Full name | Soluble TREM2 | Molecular Type | Protein (Receptor Fragment) |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Pathological Confirmation |
| Disease | Amyotrophic Lateral Sclerosis | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | CSF/Plasma (SIMOA, ELISA) | ||
| Pathobiological Mechanisms | Released after microglial activation, involved in phagocytosis regulation, reflecting the degree of neuroinflammation. | ||||
| Clinical Availability Status | Research exploration stage | ||||
| Notes and Dynamics | CSF sTREM2 levels are positively correlated with YKL-40; levels in C9orf72 mutant patients are significantly higher than in sporadic ALS. | ||||