Parameter
| Biomarker | [18F]-FDG (PET) | Full name | [18F]-FDG (PET Imaging) | Molecular Type | Imaging Biomarker |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Pathological Confirmation, Diagnosis |
| Disease | Amyotrophic Lateral Sclerosis | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Brain (PET Imaging) | ||
| Pathobiological Mechanisms | Reflects intracerebral glucose metabolism; decreased metabolism in the motor cortex and prefrontal lobe indicates abnormal neuronal function. | ||||
| Clinical Availability Status | Research validation stage | ||||
| Notes and Dynamics | [18F]-FDG uptake in the motor cortex of ALS patients is 25% lower than in healthy individuals, negatively correlated with NfL levels; distinguishes ALS from FTD (accuracy 82%). | ||||