Parameter
| Biomarker | 1p/19q Co-Deletion | Full name | 1p/19q Co-Deletion | Molecular Type | Chromosomal Abnormality |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Prognosis |
| Disease | Glioblastoma | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Tumor Tissue (Fluorescence In Situ Hybridization FISH, Comparative Genomic Hybridization CGH) | ||
| Pathobiological Mechanisms | Deletion of fragments on the short arm of chromosome 1 and long arm of chromosome 19 is associated with oligodendrocyte differentiation, rare in GBM but indicating higher tumor differentiation. | ||||
| Clinical Availability Status | Under clinical validation | ||||
| Notes and Dynamics | Mainly seen in oligodendrogliomas; GBM patients with this deletion are significantly more sensitive to radiotherapy and chemotherapy than those without, with a 10%-15% increase in 5-year survival rate. | ||||