Parameter
| Biomarker | TNF-α | Full name | Tumor Necrosis Factor α | Molecular Type | Protein |
|---|---|---|---|---|---|
| Molecular Formula | / | Molecular Weight | / | Core Functional Dimensions | Diagnosis, Prognosis, Prediction |
| Disease | Schizophrenia | Disease Subtypes | / | ||
| Organ | Brain | Test Sample / Technology Platform | Serum/Plasma (ELISA, Luminex) | ||
| Pathobiological Mechanisms | Induces astrocyte activation, reduces presynaptic serotonin release, and mediates inflammation and apoptosis pathways through TNFR1. | ||||
| Clinical Availability Status | Under clinical validation | ||||
| Notes and Dynamics | The gene polymorphism (-238G/A) is associated with treatment resistance; anti-TNF-α therapy has potential value. | ||||